Association of SNPs in miR-146a, miR-196a2, and miR-499 with the risk of endometrial/ovarian cancer
نویسندگان
چکیده
منابع مشابه
miR-146a and miR-196a2 polymorphisms in ovarian cancer risk.
We investigated the relationship between miR-146a and miR-196a2 genetic polymorphisms and development of ovarian cancer in a Chinese population. A total of 134 patients and 227 control subjects were involved in our study between January 2012 and October 2014 from China-Japan Union Hospital of Jilin University. Genotyping of miR-146a and miR-196a2 was accomplished by polymerase chain reaction co...
متن کاملAssociation of miR-146a, miR-149, miR-196a2, miR-499 gene polymorphisms with ischemic stroke in a Chinese people
This study aimed to investigate genetic polymorphisms of miR-146a, miR-149, miR-196a2, and miR-499 and genetic susceptibility of ischemic stroke in the population of Guangxi in China. A case-control study was used to investigate miRNAs genetic polymorphisms in 298 patients with ischemic stroke and 303 healthy controls. Single-base extension polymerase chain reaction genotyping principle was use...
متن کاملAssociation of miR-196a2 rs11614913 and miR-499 rs3746444 polymorphisms with cancer risk: a meta-analysis
Background MicroRNAs (miRNAs) are small non-coding RNA molecules, which participate in diverse biological processes and may regulate tumor suppressor genes or oncogenes. Rs11614913 in miR-196a2 and rs3746444 in miR-499 are shown to associate with increased/decreased cancer risk. This meta-analysis was performed to systematically assess the overall association. Materials and Methods We searche...
متن کاملAssociations of SNPs in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility
Colorectal cancer (CRC) is the fourth most common cause of death from cancer and the most common malignancy of the gastrointestinal tract. About 608, 000 deaths are estimated worldwide, accounting for 8% of all cancer deaths (Ferlay et al., 2010). The five-year survival rate of early-stage CRC is 90%, but only 10% if distant metastases are present (Levin et al., 2008). Though the recent statist...
متن کاملAssociation of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk.
OBJECTIVE MicroRNAs play a role in atherosclerosis-related diseases, such as cerebrovascular or cardiovascular disease. However, the effect of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported. METHODS AND RESULTS Using polymerase chain reaction-amplified DNA, microRNA polymorphisms were analyzed in 678 pat...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2015
ISSN: 1672-9145,1745-7270
DOI: 10.1093/abbs/gmv042